PSMA8

Cilia effects upon perturbation of PSMA8

Ciliogenesis screen results (1 screen)

• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

spermatogenesis defect, small thymus, abnormal semil vesicle morphology, germ cell defect, cytoskeletal defect, increased monocyte cell number, abnormal skin morphology, small epididymis, enlarged uriry bladder, hypoplasia

Mouse ciliopathy phenotype:

small testis, abnormal pancreas morphology, male infertility, enlarged kidney

Subcellular localization

cytosol, flagella, nucleus

Functional category

• Viral interactions
• Signaling (Hedgehog, GPCRs, ion channels)
• Transcription regulation

Function

PSMA8 has localized in flagella.