PSMC4

proteasome 26S subunit, ATPase 4

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000281221
UniProt:
P43686
OMIM:
602707
Synonyms:
MGC13687, MGC23214, MGC8570, MIP224, RPT3, S6, TBP-7, TBP7

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-12.69) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.38, ciliated=55.8%) PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=4.97) PMID:20393562

Subcellular localization

basal body, cytosol, nucleus

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Metabolism
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

PSMC4 has localized in basal body.