PTEN
phosphatase and tensin homolog
- Ensembl:
- ENSG00000284792, ENSG00000171862
- UniProt:
- P60484
- OMIM:
- 601728
- Synonyms:
- BZS, MHAM, MMAC1, PTEN1, TEP1
Cilia effects upon perturbation of PTEN
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Longer cilia
- Overexpression effect:
- Decreased
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.98) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.5) PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
autophagosomes, cilia, cytosol, nucleus
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Reproduction & sperm
- Neurogenesis & migration
- Protein processing & maturation
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
- Transcription regulation
Function
PTEN did not co-localize with BB markers, such as gamma-tubulin or RFP-tagged Centrin, but rather was observed adjacent to BBs, as well as in a spotted pattern in the ciliary axoneme itself , suggesting direct functio l involvement of PTEN in the regulation of ciliogenesis (26399523).