PTGIS

Phenotypes

Mouse phenotype:

abnormal thymus morphology; enlarged lymph nodes; necrosis; decreased mean corpuscular volume; increased blood urea nitrogen level; abnormal lymph node morphology; increased mean corpuscular hemoglobin concentration; increased red blood cell distribution width; increased circulating alkaline phosphatase level; increased circulating cholesterol level; chronic inflammation; increased brain size; increased circulating HDL cholesterol level; enlarged thymus

Mouse ciliopathy phenotype:

decreased kidney weight; abnormal testis morphology; small kidney; abnormal kidney morphology; increased heart weight; polycystic kidney; abnormal brain morphology; increased circulating creatinine level; fibrosis; small testis

Subcellular localization

basal body, cilia, cytosol

Functional category

• Metabolism

Function

PTGIS has localized in cilia, basal body.