PTGS1

prostaglandin-endoperoxide synthase 1

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000095303
UniProt:
P23219
OMIM:
176805
Synonyms:
COX1, PGHS-1, PTGHS

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-9.52) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
enlarged cecum, abnormal cecum morphology
Human ciliopathy phenotype:
cataract

Subcellular localization

lysosomes, nucleus

References: PMID:33176142

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

ptgs1 overexpression rescues ciliogenesis and renal multiciliated cells in ppargc1a-deficient embryos ( 33176142).