PTGS1

prostaglandin-endoperoxide synthase 1

Ensembl:
ENSG00000095303
UniProt:
P23219
OMIM:
176805
Synonyms:
COX1, PGHS-1, PTGHS

Cilia effects upon perturbation of PTGS1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-9.52) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
enlarged cecum, abnormal cecum morphology
Mouse ciliopathy phenotype:
abnormal auditory brainstem response
Human ciliopathy phenotype:
cataract

Subcellular localization

cilia associated gene, lysosomes, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

ptgs1 overexpression rescues ciliogenesis and re l multiciliated cells in ppargc1a-deficient embryos ( 33176142).

Model organism evidence

Danio rerio (3 references)

We reported that emx2 regulates prostaglandin biosynthesis in ciliogenesis and renal fate changes through key factors including ppargc1a, ptgs1 and PGE2.

These phenotypes were consistent with interruptions in prostaglandin signaling, and we found that ciliogenesis was rescued by PGE2 or the cyclooxygenase enzyme Ptgs1.

PMIDs: 39687012, 37232416, 30685088

Mus musculus (1 reference)

These phenotypes were consistent with interruptions in prostaglandin signaling, and we found that ciliogenesis was rescued by PGE2 or the cyclooxygenase enzyme Ptgs1.

PMIDs: 37232416