PTGS2
prostaglandin-endoperoxide synthase 2
Tier: Cilia-Associated Genes
- Ensembl:
- ENSG00000073756
- UniProt:
- P35354
- OMIM:
- 600262
- Synonyms:
- COX2
Cilia effects upon perturbation of PTGS2
- Loss-of-function effect:
- COX-2 inhibition blocks DHA-induced cilia elongation (neurons)
Subcellular localization
No ciliary localization reported (cilia-associated gene).
Function
DHA selectively induces COX-2 at mRNA and protein level in neurons, and COX-2 activity is required for DHA-induced primary cilium elongation; COX-2-derived PGE2 acts through EP4 (PTGER4) (PMID 42871245).