PTH
parathyroid hormone
- Ensembl:
- ENSG00000152266
- UniProt:
- P01270
- OMIM:
- 168450
- Synonyms:
- PTH1
Cilia effects upon perturbation of PTH
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- increased bone mineral density
- Mouse ciliopathy phenotype:
- decreased circulating calcium level, abnormal reti morphology
Subcellular localization
cilia associated gene
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Protein processing & maturation
- Signaling (Hedgehog, GPCRs, ion channels)
- ECM & connective tissue
Function
PTH could regulate SW1353 cells primary cilia assembly ( 25365173).