PTH1R

parathyroid hormone 1 receptor

Ensembl:
ENSG00000160801
UniProt:
Q03431
OMIM:
168468
Synonyms:
PTHR, PTHR1

Cilia effects upon perturbation of PTH1R

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-9.18) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, decreased bone mineral content, increased grip strength, decreased lean body mass, increased total body fat amount

Subcellular localization

cilia, endosome, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • ECM & connective tissue

Function

PTH1R activation induces prosurvival actions via primary cilia- and Gli-1-dependent mechanism and modulates osteogenic responses via a primary cilia-dependent and Gli-1-independent pathway in osteocytes and osteoblasts(32039485).