PTK2

protein tyrosine kinase 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000169398
UniProt:
Q05397
OMIM:
600758
Synonyms:
FADK, FAK, FAK1, PPP1R71

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.91) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.39) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol, nucleus, ciliary tip

References: PMID:41005307, PMID:24434137, PMID:27895123

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Viral interactions
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Axon guidance & growth

Function

Interacts with both basal bodies and actin, its downregulation leads to defects in ciliogenesis (24434137). It is a regulator of the actin cytoskeleton, cell adhesion, migration and plays a scaffolding role in multiciliated cells (27895123).