PTPDC1

protein tyrosine phosphatase domain containing 1

Ensembl:
ENSG00000158079
UniProt:
A2A3K4
Synonyms:
FLJ37312, PTP9Q22

Cilia effects upon perturbation of PTPDC1

Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=3.19) PMID:20393562

Phenotypes

Mouse phenotype:
decreased bone mineral content, increased circulating phosphate level

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly

Function

Involved in centrosomal duplication, cytokinesis, and plays a role in ciliary length determi tion (19284988, 21289087). Depletion may lengthen cilia and accumulate higher levels of Gli3 via increased anterograde transport (21289087).