PTPN11

protein tyrosine phosphatase non-receptor type 11

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000179295
UniProt:
Q06124
OMIM:
176876
Synonyms:
BPTP3, NS1, PTP2C, SH-PTP2, SHP-2, SHP2

Cilia effects upon perturbation of PTPN11

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.09) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.88) PMID:41160700

Subcellular localization

cilia, cytosol, nucleus

References: PMID:25919282

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • ECM & connective tissue
  • Transcription regulation

Function

Also called SHP2. Responsible for craniofacial skeletal formation by regulation of primary cilia formation in chondrocytes, especially in the craniofacial region. Positively regulates ciliogenesis through IFT regulation in condyle cartilage. Deficiency shortens length and reduces number of primary cilia (25919282).