PTPRK

protein tyrosine phosphatase receptor type K

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000152894
UniProt:
Q15262
OMIM:
602545
Synonyms:
R-PTP-KAPPA

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
hyperactivity, abnormal coat/hair pigmentation

Subcellular localization

basal body, flagella

References: PMID:25613900

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

PTPRK has localized in basal body,flagella.