PTPRM

protein tyrosine phosphatase receptor type M

Ensembl:
ENSG00000173482
UniProt:
P28827
OMIM:
176888
Synonyms:
HR-PTPU, PTPRL1, RPTPU

Cilia effects upon perturbation of PTPRM

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.98) PMID:41160700

Phenotypes

Mouse phenotype:
increased circulating creatine kise level, abnormal circulating glucose level
Mouse ciliopathy phenotype:
abnormal heart morphology, enlarged heart

Subcellular localization

cilia, lysosomes

Functional category

  • Ciliary assembly/disassembly
  • Neurogenesis & migration
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth

Function

PTPRM co localized with arl13b in cilia