PTTG1

PTTG1 regulator of sister chromatid separation, securin

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000164611
UniProt:: O95997
OMIM:: 604147
Synonyms:: EAP1, ECRAR, HPTTG, PTTG, SECURIN, TUTR1

Ciliogenesis screen results (4 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.36) PMID:41160700

Phenotypes

Mouse phenotype:: hypoplasia, preweaning lethality, incomplete penetrance, osteopenia, increased circulating triglyceride level, increased grip strength, abnormal semil vesicle morphology, small spleen

Subcellular localization

cilia, cytosol, nucleus

References: PMID:41005307

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

PTTG1 is a microtubule-associated protein that is a positive regulator of SHH signaling, rendering the pathway more resilient to disturbances, and PTTG1 is a component of primary cilia in the neuroepithelium(34463328).

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