RAB10
RAB10, member RAS oncogene family
- Ensembl:
- ENSG00000084733
- UniProt:
- P61026
- OMIM:
- 612672
Cilia effects upon perturbation of RAB10
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Shorter cilia
- Overexpression effect:
- No effect
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.48) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- iris synechia, decreased mean corpuscular volume, preweaning lethality, complete penetrance, decreased mean corpuscular hemoglobin, increased startle reflex, embryonic lethality prior to organogenesis
- Mouse ciliopathy phenotype:
- abnormal auditory brainstem response
Subcellular localization
basal body
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Actin & cytoskeleton regulation
Function
Negative regulator of ciliogenesis. Rab10 phosphorylation enhances binding to RILPL1, which in turn strengthens its ability to block ciliogenesis (30398148). Mediates membrane protein trafficking (21856246). Interacts in a protein complex with Sec8 at the basal body (20576682).
Model organism evidence
Mus musculus (3 references)
Activating leucine-rich repeat kinase 2 (LRRK2) mutations cause Parkinson's and phosphorylation of Rab10 by pathogenic LRRK2 blocks primary ciliogenesis in cultured cells.
We previously reported that Tbc1d21-null mice exhibit severe sperm tail defects with a disrupted axoneme, and that TBC1D21 interacts with RAB10.