RAB11A

RAB11A, member RAS oncogene family

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000103769
UniProt:
P62491
OMIM:
605570
Synonyms:
YL8

Cilia effects upon perturbation of RAB11A

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, improved glucose tolerance, embryonic lethality prior to organogenesis

Subcellular localization

basal body, cilia, endosome

References: PMID:41005307, PMID:20308558, PMID:31204173, PMID:22718902

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane

Function

Regulator of the endocytic recycling compartment (ERC), binds to Rabin8 and transport it to the centrosome where it activates Rab8 to assemble the ciliary membrane from the ciliary vesicle (20308558, 31204173, 22718902). Rabin8- Rab11a interaction and preciliary trafficking are promoted by PI3K and Akt inhibitors (31204173).