RAB11B

RAB11B, member RAS oncogene family

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000185236
UniProt:
Q15907
OMIM:
604198
Synonyms:
H-YPT3

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.16) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.42, ciliated=56.1%) PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.47) PMID:41160700

Phenotypes

Mouse phenotype:
decreased mean corpuscular hemoglobin concentration, decreased mean corpuscular volume, decreased mean corpuscular hemoglobin

Subcellular localization

cilia, basal body

References: PMID:41005307, PMID:20308558

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

Localization of Rab11 at the base of the primary cilia(20308558).