RAB11FIP3

Cilia effects upon perturbation of RAB11FIP3

Loss-of-function effect:

No effect

Ciliogenesis screen results (1 screen)

• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

improved glucose tolerance, increased vertical activity, abnormal behavior, decreased thigmotaxis, abnormal startle reflex, decreased startle reflex

Mouse ciliopathy phenotype:

abnormal auditory brainstem response

Subcellular localization

centrosome, cilia, endosome, nucleus

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Signaling (Hedgehog, GPCRs, ion channels)
• Ciliary membrane

Function

Also known as FIP3. Rab11 effector, required for regulation of preciliary trafficking and ciliogenesis. FIP3 increases Rabin8 affinity for Rab11 and forms a complex with them (31204173). Interact with Arf4, ASAP1 and Rab11 to form a complex that regulates budding of post-Trans-Golgi Network carriers targeted to the primary cilia (19153612), which meand that FIP3 is an essential regulator of ciliary membrane targeting, expansion and compartmentalisation of sig ling receptors (25673879)