RAB11FIP4

RAB11 family interacting protein 4

Ensembl:
ENSG00000131242
UniProt:
Q86YS3
OMIM:
611999
Synonyms:
FLJ00131, KIAA1821, MGC11316, RAB11-FIP4

Cilia effects upon perturbation of RAB11FIP4

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
decreased thigmotaxis, hyperactivity, decreased startle reflex, abnormal behavior, increased exploration in new environment
Mouse ciliopathy phenotype:
abnormal reti morphology

Subcellular localization

endosome, flagella

Functional category

  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation

Function

RAB11FIP4 has localized in flagella.