RAB13
RAB13, member RAS oncogene family
- Ensembl:
- ENSG00000143545
- UniProt:
- P51153
- OMIM:
- 602672
Cilia effects upon perturbation of RAB13
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Shorter cilia
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.49) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
cilia associated gene
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Actin & cytoskeleton regulation
- Cell migration & adhesion
Function
Localizes to the trans-Golgi network (TGN) and recycling endosomes (RE) in polarized epithelial cells. Required for TGN identity and proper trafficking of proteins through the TGN → RE → plasma membrane pathway. Disruption of Rab13 (knockdown or mutants) impairs trafficking via this route, which is relevant for ciliary protein sorting, as many ciliary proteins pass through similar pathways(PMID: 18779367).
Model organism evidence
C. elegans (2 references)
Finally, genetic analyses reveal that the ciliary membrane expansions in dynamin and AP-2 mutants require bbs-8 and rab-8 function and that sensory signaling and endocytic genes may function in a common pathway to regulate ciliary membrane volume.
elegans ciliary membrane transport.