RAB17

RAB17, member RAS oncogene family

Ensembl:
ENSG00000124839
UniProt:
Q9H0T7
OMIM:
602206

Cilia effects upon perturbation of RAB17

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.43) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.14, ciliated=54.0%) PMID:26595381

Subcellular localization

cilia, endosome

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation

Function

Involved in membrane trafficking, necessary for ciliogenesis (17646400). Involved in the function of apical sorting endosomes in polarized epithelial cells (9490718)