RAB19

Cilia effects upon perturbation of RAB19

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.81) PMID:41160700

Phenotypes

Mouse phenotype:

increased eosinophil cell number, decreased large unstained cell number, abnormal cornea morphology, increased cornea thickness, cornea opacity, abnormal contextual conditioning behavior

Mouse ciliopathy phenotype:

decreased circulating calcium level, increased heart weight, persistence of hyaloid vascular system

Subcellular localization

basal body

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Ciliary membrane

Function

RAB19 associates with the RAB-GAP TBC1D4 and the HOPS-tethering complex to coordi te cortical clearing and ciliary membrane growth, which is essential for ciliogenesis(33561422).