RAB1A

RAB1A, member RAS oncogene family

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000138069
UniProt:
P62820
OMIM:
179508
Synonyms:
RAB1, YPT1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.89) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
abnormal vibrissa morphology, preweaning lethality, complete penetrance

Subcellular localization

basal body

References: PMID:30125442

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Viral interactions

Function

Polycystin-1 (PC1) colocalizes with Rab1a, and PC1 may transit through the Rab1a-positive intermediate compartment en route to the cilium(30125442).