RAB1A

RAB1A, member RAS oncogene family

Ensembl:
ENSG00000138069
UniProt:
P62820
OMIM:
179508
Synonyms:
RAB1, YPT1

Cilia effects upon perturbation of RAB1A

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.89) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
abnormal vibrissa morphology, preweaning lethality, complete penetrance

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Viral interactions

Function

Polycystin-1 (PC1) colocalizes with Rab1a, and PC1 may transit through the Rab1a-positive intermediate compartment en route to the cilium(30125442).

Model organism evidence

Mus musculus (1 reference)

Following SI, sera of mice were used for immunoproteomics, which led to the identification of 30 proteins, of which four proteins namely sperm head protein 1, sperm flagella protein 2 (SFP2), SFP3, and SFP4 are being reported for the first time on sperm.

PMIDs: 19423663