RAB29

RAB29, member RAS oncogene family

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000117280
UniProt:: O14966
OMIM:: 603949
Synonyms:: RAB7L, RAB7L1

Cilia effects upon perturbation of RAB29

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body

References: PMID:26021297

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Ciliary membrane

Function

Colocalizes and interacts with Rab8, Rab11 and IFT20. Participates in ciliogenesis by controlling cilium growth, by promoting the transport of endosome-associated ciliary cargo to the base of the cilium. Required for Smo trafficking to the ciliary membrane.

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