RAB3IP

Cilia effects upon perturbation of RAB3IP

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

decreased bone mineral density, abnormal bone structure, decreased bone mineral content, increased circulating alkaline phosphatase level, increased lean body mass, increased mean corpuscular volume, increased mean corpuscular hemoglobin, decreased exploration in new environment

Subcellular localization

centrosome, cilia, cytosol, flagella, nucleus

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Ciliary membrane

Function

Also known as Rabin8. GTP loading by Rabin8 promotes Rab8 association with post- Golgi vesicles and targets them to polarised areas of the plasma membrane. BBS1 subunit of the BBSome associates with the C terminus of Rabin8 at the basal body. Activates Rab8 by loading with GTP, which is necessary for Rab8 to enter the primary cilium, promoting ciliogenesis and apical membrane formation (17574030). Phosphorylation of Rabin8 might modulate its interactions with ASAP1 and Rab11a. It binds to the catalytically active ASAP1 in complex with Rab11a and FIP3 (25673879). Interacts with Chibby to promote recruitment of Rab8 and efficient assembly of ciliary vesicles. Interaction with Rab11 stimulates its GEF activity (25313408) and is required for Rabin8 preciliary membrane trafficking to the centrosome and for ciliogenesis (21273506).

Model organism evidence