RAB6A

RAB6A, member RAS oncogene family

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000175582
UniProt:
P20340
OMIM:
179513
Synonyms:
RAB6

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.27) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=154, lfc=0.88) PMID:30270045

Subcellular localization

basal body, cytosol

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation

Function

RAB6A has localized in basal body.