RAB6A

RAB6A, member RAS oncogene family

Ensembl:
ENSG00000175582
UniProt:
P20340
OMIM:
179513
Synonyms:
RAB6

Cilia effects upon perturbation of RAB6A

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.27) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=154, lfc=0.88) PMID:30270045

Subcellular localization

basal body, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation

Function

RAB6A has localized in basal body.

Model organism evidence

Mus musculus (1 reference)

The ins and outs of the Arf4-based ciliary membrane-targeting complex.

PMIDs: 31068062

Danio rerio (1 reference)

Mutations in the Dynein1 Complex are Permissible for Basal Body Migration in Photoreceptors but Alter Rab6 Localization.

PMIDs: 26427413