RAB6B

RAB6B, member RAS oncogene family

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000154917
UniProt:
Q9NRW1
OMIM:
615852

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.80) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
hyperactivity, decreased thigmotaxis, abnormal behavior, decreased grip strength, decreased prepulse inhibition

Subcellular localization

basal body

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

RAB6B has localized in basal body.