RAB7A

RAB7A, member RAS oncogene family

Ensembl:
ENSG00000075785
UniProt:
P51149
OMIM:
602298
Synonyms:
CMT2B, RAB7

Cilia effects upon perturbation of RAB7A

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.42) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.26) PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=56, lfc=-3.46) PMID:30270045

Subcellular localization

endosome, transition zone

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • T cell biology
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone

Function

The small GTPase RAB7A lozalized in the transition zone

Model organism evidence

Drosophila (1 reference)

OCRL plays diverse roles in endocytic and endolysosomal trafficking, cytokinesis, and ciliogenesis, but it is unclear which of these cellular functions underlie specific patient symptoms.

PMIDs: 29028801