RAB7A

RAB7A, member RAS oncogene family

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000075785
UniProt:
P51149
OMIM:
602298
Synonyms:
CMT2B, RAB7

Cilia effects upon perturbation of RAB7A

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.42) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.26) PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=56, lfc=-3.46) PMID:30270045

Subcellular localization

endosome, transition zone

References: PMID:41005307, PMID:31619485

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone

Function

The small GTPase RAB7A lozalized in the transition zone