RABEP1

rabaptin, RAB GTPase binding effector protein 1

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000029725
UniProt:: Q15276
OMIM:: 603616
Synonyms:: NEUROCRESCIN, RAB5EP, RABAPTIN-5, RABPT5

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.98) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:25405894

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Signaling (Hedgehog, GPCRs, ion channels)
Ciliary membrane

Function

Rabep1/GGA1/Arl3-dependent ciliary targeting mechanism, whereby Rabep1 couples the polycystin complex to a GGA1/Arl3-based ciliary trafficking module at the TGN ( 25405894).

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