RABEP2

rabaptin, RAB GTPase binding effector protein 2

Ensembl:: ENSG00000177548
UniProt:: Q9H5N1
OMIM:: 611869
Synonyms:: FLJ23282, FRA

Cilia effects upon perturbation of RABEP2

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, nucleus

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

RABEP2 localization at the centrosome is regulated by SDCCAG8. As a component of cilium, it may be a component of the intraciliary transport mechanism. siR mediated knockdown in hTERT-RPE1 cells abolished cilia formation, indicating a critical role in ciliogenesis (27224062).

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