RABL3

RAB, member of RAS oncogene family like 3

Ensembl:
ENSG00000144840
UniProt:
Q5HYI8
OMIM:
618542
Synonyms:
MGC23920

Cilia effects upon perturbation of RABL3

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia /absent

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.71) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • T cell biology

Function

Atypical small GTPase RAB-like 3 (RABL3) plays an important role, in cooperation with RAB11, in CV formation during early ciliogenesis(36052645).