RABL6
RAB, member RAS oncogene family like 6
- Ensembl:
- ENSG00000196642
- UniProt:
- Q3YEC7
- OMIM:
- 610615
- Synonyms:
- BA216L13.9, C9ORF86, FLJ10101, FLJ13045, PARF
Cilia effects upon perturbation of RABL6
Ciliogenesis screen results (1 screen)
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- increased bone mineral content, inflammation, increased lean body mass, increased bone mineral density
- Mouse ciliopathy phenotype:
- cataract
Subcellular localization
cilia, nucleus
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Function
RABL6 has localized in cilia.
Model organism evidence
Mus musculus (1 reference)
Type III adenylyl cyclase (AC3, ADCY3) is predominantly enriched in neuronal primary cilia throughout the central nervous system (CNS).
PMIDs: 30814930