RACGAP1

Rac GTPase activating protein 1

Ensembl:
ENSG00000161800
UniProt:
Q9H0H5
Synonyms:
CYK4, MGCRACGAP

Cilia effects upon perturbation of RACGAP1

Cilia number / % ciliated:
Unknown
Loss-of-function effect:
Supernumerary cilia
Overexpression effect:
Unknown

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.28) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Basu et al. 2023 (siRNA) [siRNA]: Left-Right Asymmetry Defect (Z2MCilia=10.14, increased) PMID:37771269
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, cytosol, endosome, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation

Function

Loss of RACGAP1, mother centrioles were specified correctly prior to ciliogenesis and the cilia appeared normal, Racgap1 knockdown results in cells with multiple cilia due to cytokinesis failure ( 37771269).Loss of RACGAP1 gene cause supernumerary cilia(PMID: 37771269).