RACK1

receptor for activated C kinase 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000204628
UniProt:: P63244
OMIM:: 176981
Synonyms:: GNB2-RS1, GNB2L1, H12.3

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680

Subcellular localization

basal body

References: PMID:30617304

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Signaling (Hedgehog, GPCRs, ion channels)

Function

RACK1 regulates centriole duplication by controlling the centrosomal localization of BRCA1 in mammary tissue-derived cells and that this is dependent on the BRCA1–RACK1 interaction(30617304).

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