RACK1

receptor for activated C kinase 1

Ensembl:
ENSG00000204628
UniProt:
P63244
OMIM:
176981
Synonyms:
GNB2-RS1, GNB2L1, H12.3

Cilia effects upon perturbation of RACK1

Ciliogenesis screen results (1 screen)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

RACK1 regulates centriole duplication by controlling the centrosomal localization of BRCA1 in mammary tissue-derived cells and that this is dependent on the BRCA1鈥揜ACK1 interaction(30617304).

Model organism evidence

Mus musculus (1 reference)

The RNAi cells undergo multiple rounds of partial cytokinesis and accumulate nuclei and cytoplasmic extensions with attached flagella.

PMIDs: 16469736