RAD51D

RAD51 paralog D

Ensembl:: ENSG00000185379
UniProt:: O75771
OMIM:: 602954
Synonyms:: HSTRAD, R51H3, RAD51L3, TRAD

Cilia effects upon perturbation of RAD51D

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.98) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=509, lfc=0.78) PMID:30270045

Subcellular localization

cilia associated gene

Functional category

Ciliary assembly/disassembly
Metabolism
Cell migration & adhesion

Function

The co-deletion of TP53 and RAD51D downregulated cilia assembly, development, and motility, but upregulated multiple HGSOC-associated pathways, including the IL-17 signaling pathway. IL-17A treatment significantly improved cell viability(PMID: 38255960).

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