RALGAPA1

Ral GTPase activating protein catalytic subunit alpha 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000174373
UniProt:: Q6GYQ0
OMIM:: 608884
Synonyms:: DKFZP667F074, GARNL1, GRIPE, KIAA0884, RALGAPALPHA1, TULIP1

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance, hyperactivity, abnormal locomotor behavior, decreased exploration in new environment, limb grasping

Subcellular localization

flagella, nucleus

References: PMID:25613900

Functional category

Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

RALGAPA1 has localized in flagella.

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