RALGAPA1

Ral GTPase activating protein catalytic subunit alpha 1

Ensembl:: ENSG00000174373
UniProt:: Q6GYQ0
OMIM:: 608884
Synonyms:: DKFZP667F074, GARNL1, GRIPE, KIAA0884, RALGAPALPHA1

Cilia effects upon perturbation of RALGAPA1

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance, hyperactivity, abnormal locomotor behavior, decreased exploration in new environment, limb grasping

Subcellular localization

flagella, nucleus

Functional category

Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

RALGAPA1 has localized in flagella.

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