RANBP10

Cilia effects upon perturbation of RANBP10

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.01) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

increased circulating glucose level

Mouse ciliopathy phenotype:

abnormal heart morphology, enlarged heart

Subcellular localization

cilia associated gene

Functional category

• Ciliary assembly/disassembly
• Signaling (Hedgehog, GPCRs, ion channels)

Function

The GID/CTLH complex, including RANBP9 and RANBP10, has been identified as a component of the primary cilium. It is involved in ciliary signal transduction, particularly in pathways like Sonic Hedgehog (Shh) signaling. Disruption of this complex leads to ciliopathy-like phenotypes(PMID: 35543155).