RANBP9

RAN binding protein 9

Ensembl:: ENSG00000010017
UniProt:: Q96S59
OMIM:: 603854
Synonyms:: RANBPM

Cilia effects upon perturbation of RANBP9

Ciliogenesis screen results (4 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Basu et al. 2023 (siRNA) [siRNA]: Left-Right Asymmetry Candidate (Z2MCilia=-1.12) PMID:37771269
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)

Function

The GID/CTLH complex, including RANBP9 and RANBP10, has been identified as a component of the primary cilium. It is involved in ciliary signal transduction, particularly in pathways like Sonic Hedgehog (Shh) signaling. Disruption of this complex leads to ciliopathy-like phenotypes(PMID: 35543155).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.