RAP1GAP2

RAP1 GTPase activating protein 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000132359
UniProt:
Q684P5
OMIM:
618714
Synonyms:
GARNL4, KIAA1039

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
hyperactivity, increased aggression, increased circulating phosphate level

Subcellular localization

basal body, centrosome, cytosol, nucleus

References: PMID:21399614

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

GARNL4 localized to centrosome (21399614).