RAPGEF3

Rap guanine nucleotide exchange factor 3

Ensembl:
ENSG00000079337
UniProt:
O95398
OMIM:
606057
Synonyms:
BCM910, CAMP-GEFI, EPAC

Cilia effects upon perturbation of RAPGEF3

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.87, ciliated=15.6%) PMID:26595381

Subcellular localization

cilia, microtubules

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Microtubule-associated proteins (MAPs) regulate cAMP sig lling through exchange protein directly activated by cAMP (EPAC) and P2Y12 and components of the EPAC 1 - 2 (one of the AKAP sig ling complex) are expressed in cholangiocyte cilia(18687752).