RAPGEF4

Cilia effects upon perturbation of RAPGEF4

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=3.69) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

increased red blood cell distribution width, decreased fasting circulating glucose level, thrombocytopenia

Mouse ciliopathy phenotype:

decreased circulating calcium level

Subcellular localization

cilia, cytosol

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Metabolism
• Signaling (Hedgehog, GPCRs, ion channels)

Function

EPAC is expressed in cholangiocyte cilia (18687752)., Microtubule-associated proteins (MAPs) regulate cAMP sig lling through exchange protein directly activated by cAMP (EPAC) and P2Y12 and components of the EPAC 1 - 2 (one of the AKAP sig ling complex) are expressed in cholangiocyte cilia(18687752).