RB1

RB transcriptional corepressor 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000139687
UniProt:
P06400
OMIM:
614041
Synonyms:
OSRC, PPP1R130, RB

Cilia effects upon perturbation of RB1

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.49) PMID:41160700

Subcellular localization

basal body, nucleus, transition zone

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transition zone
  • ECM & connective tissue
  • Transcription regulation

Function

RB1 has localized in basal body, transition zone.