RBSN

rabenosyn, RAB effector

Ensembl:: ENSG00000131381
UniProt:: Q9H1K0
OMIM:: 609511
Synonyms:: ZFYVE20

Cilia effects upon perturbation of RBSN

Ciliogenesis screen results (1 screen)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance

Subcellular localization

periciliary membrane compartment

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Signaling (Hedgehog, GPCRs, ion channels)
Ciliary membrane

Function

Rabenosyn 5 localizes to the periciliary membrane compartment(29572244).

Model organism evidence

C. elegans (1 reference)

Here, using Caenorhabditis elegans, we describe closely linked functions for early endosome (EE) maturation factors RABS-5 (Rabenosyn-5) and VPS-45 (VPS45) in regulating cilium length and morphology, ciliary and periciliary membrane volume, and ciliary signalling-related sensory behaviour.

PMIDs: 29572244

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