RCAN2

regulator of calcineurin 2

Ensembl:: ENSG00000172348
UniProt:: Q14206
OMIM:: 604876
Synonyms:: DSCR1L1, ZAKI-4

Cilia effects upon perturbation of RCAN2

Cilia number / % ciliated:: No effect
Loss-of-function effect:: Longer cilia
Overexpression effect:: Unknown

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-18.65) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

Functional category

Ciliary assembly/disassembly
Cilia length regulation

Function

Negative regulator of calcineurin and modulates Ca2+ dependent sig lling. Required to maintain normal cilia length. Depletion in WT RPE-1 cells results in shorter cilia, whilst in giantin KO cells induces longer cilia (29643119).

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