RCBTB2

RCC1 and BTB domain containing protein 2

Ensembl:: ENSG00000136161
UniProt:: O95199
OMIM:: 603524
Synonyms:: CHC1L

Cilia effects upon perturbation of RCBTB2

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.74) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body

Functional category

Ciliary assembly/disassembly
T cell biology

Function

RC/BTB2 is a necessary component of the process of formation of primary cilia in somatic cells, perhaps through the transportation of cargos from Golgi bodies to centrosomes for cilia assembling(25762510).

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