RCC1

regulator of chromosome condensation 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000180198
UniProt:: P18754
OMIM:: 179710
Synonyms:: CHC1

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.56) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: preweaning lethality; complete penetrance; embryonic lethality prior to organogenesis

Subcellular localization

basal body, cilia, nucleoplasm

References: PMID:22106379

Functional category

Small GTPases; Metabolism

Function

RCC1 domain localized to centrosomes and cilia, while the kinase domain alone, despite being active, did not . A model for how activity regulates Nek8 localization based on the hypothesis that autophosphorylation within the non-catalytic RCC1-like domain is required to expose a ciliary-targeting site present within this domain (PMID: 22106379).

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