RCSD1

RCSD domain containing 1

Ensembl:
ENSG00000198771
UniProt:
Q6JBY9
OMIM:
610579
Synonyms:
CAPZIP, MGC21854, MK2S4

Cilia effects upon perturbation of RCSD1

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

Also known as CAPZIP. Ortholog duboraya (dub), has been reported to be essential for actin organization in the cells lining Kupffer's vesicle, regulates ciliogenesis in a phosphorylation-dependent manner as well as left-right patterning in zebrafish ( 17013396). Phosphorylated by ERK7. Ciliogenesis regulations through CapZIP, requires Dvl binding to both ERK7 and CapZIP ( 25823377).

Model organism evidence

Danio rerio (1 reference)

Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya.

PMIDs: 17013396