RELA

Cilia effects upon perturbation of RELA

Cilia number / % ciliated:

Decreased cilia number

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.14) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Neurogenesis & migration
• Viral interactions
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)
• Cardiac & muscle development
• Transcription regulation

Function

To facilitate signal detection of γH2AX–53BP1 overlap, 53BP1 images were pseudocoloured with cyan. Scale bar, 20 μm. c, Top, whereas Syn-cre injection in wild-type mice and Ifnar1 deletion did not affect the number of cilia (n = 6 mice per group, 30 neurons per mouse) and PNNs (n = 6 mice per group, one slice of dorsal CA1 per mouse), Tlr9 and Rela knockout impaired ciliogenesis and PNN formation (top, one-way ANOVA, ACIII: P < 0.0001, F(4,25) = 97.47, PNNs: P < 0.0001, F(4,25) = 23.31). Representative micrographs depicting ACIII signals (middle, red arrows, scale bar, 20 μm) and PNNs (bottom, blue arrows, scale bar, 100 μm). Wisteria floribunda lectin (WFN). Data are mean ± s.e.m. (38538785)