RFX3

regulatory factor X3

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000080298
UniProt:: P48380
OMIM:: 601337

Cilia effects upon perturbation of RFX3

Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

nucleus

References: PMID:19671664, PMID:23822649

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Protein processing & maturation
Cell migration & adhesion
Transcription regulation

Function

Transcription factor regulating expression of ciliary assembly (like Dync2li1, Foxj1 and Bbs4) and axonemal dyneins involved in ciliary motility (Dnahc11, Dnahc9 and Dnahc5), by binding directly to the promoters of their genes. Regulates the orthologs of genes involved inhuman PCD. It may also cooperate with FOXJ1 to regulate the expression of cilia genes ( 19671664). Regulates the expression of D2lic in mouse, a gene implicated in intraflagellar transport, a proces required for the assembly and maintenance of cilia. RFX3 is essential for the differentiation of nodal monocilia and for LR patterning ( 15121860). Together with FOXJ1, plays a role in modulating differentiation in multiciliated cells ( 23822649).

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