RFX3

regulatory factor X3

Ensembl:
ENSG00000080298
UniProt:
P48380
OMIM:
601337

Cilia effects upon perturbation of RFX3

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Protein processing & maturation
  • Cell migration & adhesion
  • Transcription regulation

Function

Transcription factor regulating expression of ciliary assembly (like Dync2li1, Foxj1 and Bbs4) and axonemal dyneins involved in ciliary motility (D hc11, D hc9 and D hc5), by binding directly to the promoters of their genes. Regulates the orthologs of genes involved inhuman PCD. It may also cooperate with FOXJ1 to regulate the expression of cilia genes ( 19671664). Regulates the expression of D2lic in mouse, a gene implicated in intraflagellar transport, a proces required for the assembly and mainte nce of cilia. RFX3 is essential for the differentiation of nodal monocilia and for LR patterning ( 15121860). Together with FOXJ1, plays a role in modulating differentiation in multiciliated cells ( 23822649).

Model organism evidence

Mus musculus (4 references)

Foxn3 is part of a transcriptional network that regulates primary cilia in the developing retina.

Foxn3 is required to suppress aberrant ciliogenesis in nonphotoreceptor retinal neurons.

PMIDs: 41766387, 40663603, 40009443, 39554069

Danio rerio (1 reference)

We demonstrate that the depletion of multiple components of the switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complex induces ciliopathy-like phenotypes in zebrafish embryos.

PMIDs: 41213452