RFX4

regulatory factor X4

Ensembl:
ENSG00000111783
UniProt:
Q33E94
OMIM:
603958

Cilia effects upon perturbation of RFX4

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Protein processing & maturation

Function

Modulates Shh sig ling and and Gli3 processing by regio l control of ciliogenesis and function of primary cilia. Rfx4 nuclear translocation and/or transcriptio l activity, may be regulated by phosphorylation. Required for ciliogenesis in the neural tube ( 19887680). It appears to regulate different genes than RFX3, as Rfx4 KO embryos exhibite different phenotypes from those with Rfx3 and Foxj1 mutations ( 29298325). RFX4 expression is controlled positively by RFX7 or negatively by Foxj1 during neural tube closure ( 24530844).

Model organism evidence

Mus musculus (3 references)

BACKGROUND: Rfx winged-helix transcription factors, best known as key regulators of core ciliogenesis, also play ciliogenesis-independent roles during neural development.

The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.

PMIDs: 29243319, 19887680, 15121860

Danio rerio (1 reference)

BACKGROUND: Rfx winged-helix transcription factors, best known as key regulators of core ciliogenesis, also play ciliogenesis-independent roles during neural development.

PMIDs: 29243319

Xenopus (1 reference)

RFX7 controlled the formation of cilia by regulating the expression of RFX4 gene, which has been reported to be required for ciliogenesis in the neural tube.

PMIDs: 24530844

C. elegans (1 reference)

Finally, we show that RFX3 regulates the expression of D2lic, the mouse orthologue of a Caenorhabditis elegans gene that is implicated in intraflagellar transport, a process required for the assembly and maintenance of cilia.

PMIDs: 15121860