RFX4

regulatory factor X4

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000111783
UniProt:: Q33E94
OMIM:: 603958

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

nucleus

References: PMID:19887680, PMID:29298325, PMID:24530844

Functional category

Ciliary assembly/disassembly
Protein processing & maturation

Function

Modulates Shh signaling and and Gli3 processing by regional control of ciliogenesis and function of primary cilia. Rfx4 nuclear translocation and/or transcriptional activity, may be regulated by phosphorylation. Required for ciliogenesis in the neural tube ( 19887680). It appears to regulate different genes than RFX3, as Rfx4 KO embryos exhibite different phenotypes from those with Rfx3 and Foxj1 mutations ( 29298325). RFX4 expression is controlled positively by RFX7 or negatively by Foxj1 during neural tube closure ( 24530844).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.